Reconstitute retavase only with the supplied sterile water for injection. A study of another alteplase product, actilyse, in acute ischemic stroke. Labetalol hcl has the empirical formula c 19 h 24 n 2 o 3 hcl and a molecular weight of 364. Using 2 additional 3ml syringes, withdraw normal saline equal to the remaining. Administration fda package insert, specifically for the only tissuetype plasminogen activator licensed for use in acute ischemic stroke, alteplase.
Activase alteplase for injection, for intravenous use. Remove the protective cap from one end of the transfer device and keeping the vial of sw upright, insert the piercing pin vertically into the center of the stopper of the vial of sw first. Objectiveto describe the efficacy and complications of intracameral tissue plasminogen activator tpa in a large series of glaucomatous eyes with valved glauco. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. What is the fdaapproved indication for activase in stroke. Highlights of prescribing information acute ischemic. Ceftaroline package insert pdf download to reduce the development of drugresistant bacteria and maintain the effectiveness of teflaro and. Remove the protective cap from the other end of the transfer. Appendix 4 alteplase use in hemodialysis central venous catheters contd intravenous infusion alteplase lock a. Initiate treatment as soon as possible but within 3 hours after symptom onset. Do not remove the vial adapter from the package or touch the inside of the package of the adapter. With the vial sitting on a flat surface, insert the tip of the syringe into the adapter. See tnkase package insert for instructions on the use of the dual cannula device.
Plasmin degrades the fibrin matrix of the thrombus, exerting its thrombolytic action. Lippincott nursingcenter nursing pocket card alteplase. When introduced into the systemic circulation at pharmacologic concentration, activase binds to fibrin in a thrombus and converts the entrapped. Intracameral tissue plasminogen activator use in a large. Reconstitute 100 mg vial with 100 ml sterile water provided, see package insert for detailed instructions. Rabies vaccine rx only imovax rabies rabies is transmitted. We did not include international guidelines or other international governmental restrictions on the use of alteplase because it. Frequently asked questions about activase alteplase in. Remove one of the protective caps from the transfer device and insert the. Australian product information actilyse alteplase powder for injection 1 name of the medicine alteplase rch 2 and 3 qualitative and quantitative composition and pharmaceutical form actilyse is presented as a sterile, white to offwhite, lyophilised powder, intended for intravenous. Consult package insert for complete instructions on medication preparation, reconstitution and administration. Cathflo activase alteplase is indicated for restoration of function to clotted central venous access devises as assessed by the inability to withdraw blood.
These highlights do not include all the information needed to use. For this purpose a transfer cannula is included with the pack sizes of 20 mg and. Please see full prescribing information for additional important safety information. Remove the protective cap from the other end of the transfer device. Powder for reconstitution for use in central venous access. Reconstitute activase immediately before administration. Inside the alteplase package, you should find one vial of 100 ml of preservativefree sterile water for injection, one vial of 100 mg of alteplase, and the transfer device. The activase package insert you have selected will take you away from this site to one that is not owned or controlled by genentech, inc. Begin by assembling the 50mg vial of activase, the vial of swfi usp, included with the activase package, a 50ml syringe, a largebore needle eg, 18gauge, and alcohol wipes.
Activase alteplase treatment for acute ischemic stroke ais. Contraindications cathflo activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation. Monitor patients treated with cathflo activase for signs of hypersensitivity and. Lactation there are no data on presence of activase package insert in human milk, effects on inssrt infant, or on milk production. Activase alteplase is indicated for the treatment of acute ischemic stroke ais. Intracameral tissue plasminogen activator use in a large series of eyes with valved glaucoma drainage implants. Also, prepare a polyvinyl chloride bag or glass vial along with an infusion set. It has two asymmetric centers and therefore exists as a molecular complex of two diastereoisomeric pairs. Please see accompanying full prescribing information for additional. Remove the protective cap from one end of the transfer device and keeping the vial of swfi upright, insert the piercing pin vertically into the center of the stopper of the vial of swfi. Dailymed cathflo activase alteplase injection, powder. Remove protective caps and swab the top of each vial with an alcohol wipe to reduce the risk of contamination.
Alteplase tpathrombolysis for acute stroke dosing chart concentration. Hypersensitivity hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of cathflo activase. Activase is a sterile, white to offwhite, lyophilized powder for intravenous administration after reconstitution with sterile water for injection, usp. It is synthesized using the complementary dna cdna for natural human tissue. Indications activase alteplase is indicated for the treatment of acute ischemic stroke. Alteplase tpathrombolysis for acute stroke dosing chart. Insert the exposed end all the way through the center of. Labetalol hcl is a white or offwhite crystalline powder, soluble in water. Management of acute ischemic stroke in adults, for improving neurological recovery, and reducing the incidence of disability approval date. First next 60 minutes first over 1 minute over 1 minute next 60 minutes.
Open the package containing the transfer device by peeling the paper label off the package. Alteplase is an enzyme that has the property of fibrinenhanced conversion of plasminogen. Pasteur sa is a sterile, stable, freezedried suspension of. Cathflo activase alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with sterile water for injection, usp. It is a sterile, purified glycoprotein of 527 amino acids. Frequently asked questions about activase alteplase in acute ischemic stroke. Label alteplase activase, genentech, incorporated amazon s3. Appendix alteplase use in hemodialysis central venous. Activase alteplase in acute ischemic stroke american heart. Carefully lower blood pressure bp to maintain systolic bp rtpa. It produces limited conversion of plasminogen in the absence of fibrin.